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Research Interests
Evolutionary computation
Multiobjective optimization
Systems biology and bioinformatics applications of the above
Research Projects, Past and Present
Algorithms and Analysis
- ParEGO - Bayesian multiobjective optimization (MO) algorithm based on Jones et al's EGO [ More ]
- MOCK - MO clustering algorithm incorporating
automated model
selection [ More
]
[ Mockiato (student project) ] - Performance assessment of stochastic multiobjective optimizers [ More ]
- Adaptive grid archiving - online efficient diversity-maintenance for MO [ More ]
- Hypervolume-based archiving - online convergence and diversity for MO [ More ]
- mQAP - The multiobjective quadratic assignment problem [ Benchmark instances ]
- M-PAES - hybrid MO algorithm combining local and global search [ Paper ]
- PAES - local search-based multiobjective optimizer [ More ]
Evolutionary Models and Frameworks
- Ephemeral resource constraints in optimization [ More ]
- CLEMO - Closed-loop evolutionary multiobjective optimization [ IEEE Magazine Article] ]
- Multiobjectivization - transform a fitness landscape to reduce local optima [ Paper ]
- Landscape state machines - stochastic matrix models of fitness landscapes [ Papers ]
- No-Free-Lunch theorems for MO [ Papers ]
- Neutral evolution and redundancy [ Paper ]
- Evolvability of replicators [ (1st Year) PhD student poster ] [ Animation A ] [ Animation B ]
- Cooperation in spatially structured populations [ Paper ]
Applications
- Radio Pulsar Detection (PhD project with Jodrell Bank) [ Paper ]
- Maintenance scheduling in the power industry [ Benchmarks and Results ]
- Evolution of Anti-inflammatory Combinatory Drugs [ Paper ] [ Poster ]
- Protein structure prediction methods and investigations [ More ]
- CLADE - BBSRC grant on Closed-loop aptamer directed evolution (Co-Investigator) [ More ]
- MUSCLE - BBSRC grant on mass spectrometry optimization (Principal Investigator) [ More ]
- Closed-loop optimization of analytical instruments [ Papers ]
- Husermet - BBSRC grant on large-scale study of human disease (Co-Investigator) [ More ]
- MCISB - Manchester Centre for Integrative Systems Biology (Co-Investigator) [ More ]
- Chocolate production - Early-warning recognition of water damage in cocoa beans [ Paper ]
- Constrained spanning trees in telecommunications optimization [ Papers ]
- Small molecule structure elucidation from NMR spectra [ Paper ]
- Drug manufacturability optimization [ More ]
- Radiation therapy treatment planning [ Paper ]
Closed-loop optimization of anti-inflammatory combinatory therapies.
Link to Nature Chemical Biology paper.
MOCK multiobjective clustering and model selection
- Screenshot from Mockiato -